Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents.

@article{Khera2011SynthesisAI,
  title={Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents.},
  author={Manoj Kumar Khera and Ian Anthony Cliffe and Tarun Mathur and Om Prakash},
  journal={Bioorganic & medicinal chemistry letters},
  year={2011},
  volume={21 10},
  pages={
          2887-9
        }
}
  • Manoj Kumar Khera, Ian Anthony Cliffe, +1 author Om Prakash
  • Published in
    Bioorganic & medicinal…
    2011
  • Chemistry, Medicine
  • The synthesis and antibacterial activity of 3-(4-([1,2,4]triazolo[4,3-a]pyrimidin-3-yl)phenyl)oxazolidin-2-ones is reported. Thiocarbonyl derivatives were found to be potent inhibitors of gram-positive pathogens and compound 4l was two to fourfold more potent than Linezolid. 

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