Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents.

@article{Hu2009SynthesisAI,
  title={Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents.},
  author={Laixing Hu and Maureen L Kully and David W Boykin and Norman Abood},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 5},
  pages={1292-5}
}
A new class of novel bis-benzimidazole diamidine compounds have been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Anti-MRSA and anti-VRE activities of the most potent compound 1 were more active than Vancomycin. The mechanism of action for this class of compounds appears to be different from existing antibiotics. Bis-benzimidazole diamidine compounds have potential for further investigation as a new class of potent anti-MRSA and… CONTINUE READING