Synthesis and in vitro T-cell immunogenicity of conjugates with dual specificity: attachment of epitope peptides of 16 and 38 kDa proteins from Mycobacterium tuberculosis to branched polypeptide.

@article{Wilkinson1998SynthesisAI,
  title={Synthesis and in vitro T-cell immunogenicity of conjugates with dual specificity: attachment of epitope peptides of 16 and 38 kDa proteins from Mycobacterium tuberculosis to branched polypeptide.},
  author={Katalin A Wilkinson and Hans Martin Vordermeier and Robert J Wilkinson and Juraj Iv{\'a}nyi and Ferenc Hudecz},
  journal={Bioconjugate chemistry},
  year={1998},
  volume={9 5},
  pages={539-47}
}
T-cell epitope containing peptides covalently attached to macromolecular carriers can be considered as synthetic immunogens for the development of skin-test diagnostics and of vaccines. As a carrier, an amphoteric branched chain polypeptide, poly[Lys-(Glui-DL-Alam)] (EAK) with poly(L-lysine) backbone has been used. This polypeptide with free alpha-amino and gamma-carboxyl groups at the end of the side chains was conjugated with peptides representing two immunodominant regions of the 16 and 38… CONTINUE READING
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