Synthesis and in vitro PDT activity of miscellaneous porphyrins with amino acid and uracil.

@article{Weimin2008SynthesisAI,
  title={Synthesis and in vitro PDT activity of miscellaneous porphyrins with amino acid and uracil.},
  author={Shi Weimin and Zhang Gen and Dai Guifu and Zhang Yunxiao and Zhao Jin and Tao Jingchao},
  journal={Bioorganic & medicinal chemistry},
  year={2008},
  volume={16 10},
  pages={5665-71}
}
The synthesis of a series of modularized porphyrins bearing bioactive molecule is described. Starting with meso-tetraphenylporphyrin, the compounds with two nitro functional groups were synthesized via regiospecific nitration reaction. After reduction to the amino group and subsequent coupling with l-phenylalanine or 1-carboxylmethyl-5-fluorouracil (5-Fu acid), the functionalized porphyrins were metallized with Co(II) or Mn(II) to form miscellaneous porphyrins in good yields. The spectra of all… CONTINUE READING