Synthesis and in vitro‐Anticancer and Antimicrobial Evaluation of Some Novel Quinoxalines Derived from 3‐Phenylquinoxaline‐2(1H)‐thione

@article{ElHawash2006SynthesisAI,
  title={Synthesis and in vitro‐Anticancer and Antimicrobial Evaluation of Some Novel Quinoxalines Derived from 3‐Phenylquinoxaline‐2(1H)‐thione},
  author={Soad A. M. El‐Hawash and Abeer E. Abdel Wahab},
  journal={Archiv der Pharmazie},
  year={2006},
  volume={339}
}
Two novel series derived from 3‐phenylquinoxaline‐2(1H)‐thione 2 and 2‐(hydrazinocarbonylmethylthio)‐3‐phenylquinoxaline 6 have been synthesized. Eight out of twenty six new compounds were selected at the National Cancer Institute for evaluation of their in vitro‐anticancer activity. Among them, compounds 3b, 3c, 4b, and 4c displayed moderate to strong growth inhibition activity against most of the tested sub‐panel tumor cell lines with GI50 10–5 to 10–6 molar concentrations. Compound 4b… 
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