Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems.

@article{Benaamane2008SynthesisAI,
  title={Synthesis and in silico biological activity evaluation of new N-substituted pyrazolo-oxazin-2-one systems.},
  author={Nora Benaamane and Bellara Nedjar-Kolli and Yamina Bentarzi and Lamouri Hammal and Athina A Geronikaki and Phaedra Eleftheriou and Alexey A Lagunin},
  journal={Bioorganic & medicinal chemistry},
  year={2008},
  volume={16 6},
  pages={3059-66}
}
Cyclisation of pyrazolo-beta-enaminones 3 readily obtained from 4-aceto acetyl pyrazol 2 with triphosgene led to the formation of N-substituted pyrazolo-1,3-oxazin-2-ones 4 in good yields. Estimation of pharmacotherapeutic potential, possible molecule mechanisms of action, toxic/side effects and interaction with drug-metabolizing enzymes were made for synthesised compounds on the basis of prediction of activity spectra for substances (PASS) prediction results and their analysis by PharmaExpert… CONTINUE READING