Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6.

@article{Morlacchi2014SynthesisAI,
  title={Synthesis and in Vitro Evaluation of a Peptidomimetic Inhibitor Targeting the Src Homology 2 (SH2) Domain of STAT6.},
  author={Pietro Morlacchi and Pijus Kumar Mandal and John S. McMurray},
  journal={ACS medicinal chemistry letters},
  year={2014},
  volume={5 1},
  pages={69-72}
}
An improved synthesis of a phosphopeptidomimetic prodrug targeting the Src Homology 2 (SH2) domain of signal transducer and activator of transcription 6 (STAT6) is reported. In our convergent methodology, we employed a phosphotyrosine surrogate active ester harboring pivaloyloxymethyl groups, which efficiently coupled to tert-butylglycinyl proline… CONTINUE READING