Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones.

@article{Tunbilek2003SynthesisAH,
  title={Synthesis and hypoglycemic activity of some substituted flavonyl thiazolidinedione derivatives--fifth communication: flavonyl benzyl substituted 2,4-thiazolidinediones.},
  author={Meral Tunçbilek and Oya Bozdağ-D{\"u}ndar and G{\"u}lg{\"u}n Ayhan-Kilcigil and Meltem Ceylan and Abd{\"u}l Waheed and Eugen J. Verspohl and Rahmiye Ertan},
  journal={Farmaco},
  year={2003},
  volume={58 1},
  pages={79-83}
}
A new series of 3-benzyl(p-substituted benzyl)-5-[3'-(4H-4-oxo-1-benzopyran-2-yl)-benzylidene]-2,4-thiazolidinediones (8a-e) were synthesized. These products were prepared by Knoevenagel reaction from 3'-flavone carboxaldehyde and 3-substituted 2,4-thiazolidinediones. In vitro insulinotropic activity was determined for compounds 6a-e, 7a-e, 8b and 8c.