Synthesis and hypoglycaemic activity of some new flavone derivatives. Part 1: Flavonylsulphonylurea derivatives.

Abstract

A new series of flavonyl-3'-sulphonylurea derivatives (1-7) was prepared by reaction of several isocyanates with flavone-3'-sulphonamide (III). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds 1 and 4 were able to increase insulin release in the presence of 8.3 mM glucose at least at the higher concentrations used.

Cite this paper

@article{Bozda1999SynthesisAH, title={Synthesis and hypoglycaemic activity of some new flavone derivatives. Part 1: Flavonylsulphonylurea derivatives.}, author={O Bozdağ and Eugen J. Verspohl and Rahmiye Ertan}, journal={Archiv der Pharmazie}, year={1999}, volume={332 12}, pages={435-8} }