Synthesis and hydrolysis of pppGpp in mycobacteria: a ligand mediated conformational switch in Rel.

@article{Jain2007SynthesisAH,
  title={Synthesis and hydrolysis of pppGpp in mycobacteria: a ligand mediated conformational switch in Rel.},
  author={Vikas Jain and Raspudin Saleem-Batcha and Dipankar Chatterji},
  journal={Biophysical chemistry},
  year={2007},
  volume={127 1-2},
  pages={41-50}
}
Bacteria respond to starvation by synthesizing a polyphosphate derivative of guanosine, (p)ppGpp, that helps the bacteria in surviving during stress. The protein in Gram-positive organisms required for (p)ppGpp synthesis is Rel, a bifunctional enzyme that carries out both synthesis and hydrolysis of this molecule. Rel shows increased pppGpp synthesis in the presence of uncharged tRNA, the effect of which is regulated by the C-terminal of Rel. We show by fluorescence resonance energy transfer… CONTINUE READING

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