Synthesis and hepatoprotector activity of water-soluble derivatives of aminoalkylphenols


A series of 2(4)-hydroxybenzyl-and 3-(4-hydroxyaryl)propylamines and their hydrochlorides were synthesized based on 2,4-and 2,6-alkylsubstituted phenols. The synthesized hydrophilic derivatives are characterized by average half-lethal doses (LD50), which fall within 50–170 mg/kg for intraperitoneal administration in mice. Some of the synthesized compounds in a dose of 0.1LD50 show pronounced hepatoprotector activity with respect to tetrachloromethane-induced model toxic hepatitis in mice.

DOI: 10.1007/s11094-006-0101-z

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@article{Dyubchenko2006SynthesisAH, title={Synthesis and hepatoprotector activity of water-soluble derivatives of aminoalkylphenols}, author={O. I. Dyubchenko and Viktoria V Nikulina and Alexey Markov and Natalya Kandalintseva and A. E. Prosenko and O. M. Khoshchenko and Ya. Sh. Shwarts and Michael Dushkin}, journal={Pharmaceutical Chemistry Journal}, year={2006}, volume={40}, pages={243-247} }