Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells.

@article{Dixit2006SynthesisAG,
  title={Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells.},
  author={Vivechana Dixit and Jeroen Van den Bossche and Debra M. Sherman and David H Thompson and Ronald P. Andres},
  journal={Bioconjugate chemistry},
  year={2006},
  volume={17 3},
  pages={
          603-9
        }
}
This paper reports the creation of Au nanoparticles (AuNP) that are soluble in aqueous solution over a broad range of pH and ionic strength values and that are capable of selective uptake by folate receptor positive (FR+) cancer cells. A novel poly(ethylene glycol) (PEG) construct with thioctic acid and folic acid coupled on opposite ends of the polymer chain was synthesized for targeting the AuNP to FR+ tumor cells via receptor-mediated endocytosis. These folic acid-PEG-thioctic acid… CONTINUE READING

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