Synthesis and fungicidal activity of 2-methylalkyl isonicotinates and nicotinates

  title={Synthesis and fungicidal activity of 2-methylalkyl isonicotinates and nicotinates},
  author={Bogumiła Huras and Jerzy Zakrzewski and Marian Krawczyk and Danuta Bombińska and Anna Cieniecka-Rosłonkiewicz and Alicja K. Michalczyk},
  journal={Medicinal Chemistry Research},
Homologs and analogs of 2-methylheptyl isonicotinate (new, natural antifungal and antibacterial antibiotic isolated from Streptomyces sp. 201): racemic 2-methylalkyl isonicotinates 4 and nicotinates 5 and enantiomerically enriched in the R and S isomers, 2-methylpentyl isonicotinate and nicotinate were obtained. Fungistatic activity of the compounds was evaluated. Nicotinates 5a–c show significant activity against phytopathogenic fungi: Fusarium culmorum, Phytophthora cactorum, Rhizoctonia… 

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