Synthesis and function of hepatic very-low-density lipoprotein.

  title={Synthesis and function of hepatic very-low-density lipoprotein.},
  author={G. Gibbons and D. Wiggins and A-M Brown and A-M Hebbachi},
  journal={Biochemical Society transactions},
  volume={32 Pt 1},
  • G. Gibbons, D. Wiggins, +1 author A-M Hebbachi
  • Published 2004
  • Biology, Medicine
  • Biochemical Society transactions
  • Most of the triacylglycerol (TAG) utilized for the assembly of very-low-density lipoprotein (VLDL) in the secretory apparatus of the hepatocyte is mobilized by lipolysis of the cytosolic TAG pool, followed by re-esterification. The lipases involved include arylacetamide deacetylase and/or triacylglycerol hydrolase. Some of the re-esterified products of lipolysis gain access to an apolipoprotein-B-rich VLDL precursor to form mature VLDL. Some, however, are returned to the cytosolic pool in a… CONTINUE READING