Synthesis and evaluation of water soluble pH sensitive poly (vinyl alcohol)-doxorubicin conjugates.


The accuracy of spatiotemporal control cargo delivery and release are primordial to enhance the therapeutic efficiency and decrease the undesirable effects, in this context a novel prodrug were developed based on biocompatible polyvinyl alcohol (PVA) substrate. PVA was conjugated to doxorubicin (PVA-DOX) via an acid-labile hydrazone linkage. PVA was first… (More)
DOI: 10.1080/09205063.2018.1466470


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