Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-targeted anticancer drugs.

@article{Spicer2002SynthesisAE,
  title={Synthesis and evaluation of unsymmetrical bis(arylcarboxamides) designed as topoisomerase-targeted anticancer drugs.},
  author={Julie A. Spicer and Swarna A. Gamage and Graeme Finlay and William A. Denny},
  journal={Bioorganic & medicinal chemistry},
  year={2002},
  volume={10 1},
  pages={19-29}
}
Symmetrical dimers of lipophilic intercalating chromophores linked by cation-containing chains have recently been shown to have broad-spectrum in vivo anticancer activity. We report the preparation and evaluation of a series of both symmetric and unsymmetric dimers of a variety of intercalating chromophores of varied DNA binding strength, including naphthalimides, acridines, phenazines, oxanthrenes and 2-phenylquinolines. The unsymmetrical dimers were prepared by sequential coupling of the… CONTINUE READING