Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion.

@article{Musso1993SynthesisAE,
  title={Synthesis and evaluation of the antidepressant activity of the enantiomers of bupropion.},
  author={David L Musso and Neelesh B. Mehta and F. E. Soroko and Robert M. Ferris and E B Hollingsworth and Beverly Kenney},
  journal={Chirality},
  year={1993},
  volume={5 7},
  pages={495-500}
}
The synthesis of the enantiomers of bupropion, (rac)-2-tert-butylamino-3'-chloropropiophenone 1 (Wellbutrin) is described. The enantiomers were compared with the racemate in both the tetrabenazine-induced sedation model and the inhibition of uptake of biogenic amine assay. No significant differences were found in their potencies to reverse tetrabenazine… CONTINUE READING