Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists.

@article{Xiang2004SynthesisAE,
  title={Synthesis and evaluation of spirobenzazepines as potent vasopressin receptor antagonists.},
  author={Min Amy Xiang and Robert H Chen and Keith T. Demarest and Joseph W. Gunnet and R. J. Aitken P. F. A. Look and William E Hageman and William V Murray and Donald W Combs and Mona Patel},
  journal={Bioorganic & medicinal chemistry letters},
  year={2004},
  volume={14 11},
  pages={2987-9}
}
A novel series of spirobenzazepines was synthesized and evaluated for V1a and V2 receptor antagonist activity. Compounds 8b, 8i, and 8k have shown selective V1a receptor antagonist activity. Compounds 8p and 8q were shown to be dual V1a/V2 receptor antagonists.