Synthesis and evaluation of some steroidal oximes as cytotoxic agents: structure/activity studies (I).

@article{Cui2009SynthesisAE,
  title={Synthesis and evaluation of some steroidal oximes as cytotoxic agents: structure/activity studies (I).},
  author={Jianguo Cui and Lei Fan and Li-Liang Huang and Hong-Li Liu and Ai-min Zhou},
  journal={Steroids},
  year={2009},
  volume={74 1},
  pages={62-72}
}
The side chain of a compound plays an important role in its biological function. In our studies, we have found that hydroximinosteroid derivatives with different side chains and position of hydroximino on ring A and B displayed remarkable distinct cytotoxicities against a diversity of cancer cell types. Presence of an oxime group on ring B and a hydroxy on ring A or B resulted in a higher cytotoxicity than other structural motifs. In addition, a cholesterol-type side chain at position 17 was… CONTINUE READING

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