Synthesis and evaluation of radioiodinated (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter

@article{Kanegawa2005SynthesisAE,
  title={Synthesis and evaluation of radioiodinated (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter},
  author={Naoki Kanegawa and Yasushi Kiyono and Hiroyuki Kimura and Taku Sugita and Satomi Kajiyama and Hidekazu Kawashima and Masashi Ueda and Yuji Kuge and Hideo Saji},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2005},
  volume={33},
  pages={639-647}
}
Abnormality of the brain norepinephrine transporter (NET) has been reported in several psychiatric and neuronal disorders. Since NET is an important target for the diagnosis of these diseases, the development of radiopharmaceuticals for imaging of brain NET has been eagerly awaited. In this study, we synthesized (S,S)-2-(α-(2-iodophenoxy)benzyl)morpholine [(S,S)-IPBM], a derivative of reboxetine iodinated at position 2 of the phenoxy ring, and evaluated its potential as a radiopharmaceutical… CONTINUE READING
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