Synthesis and evaluation of racemic [(11)C]NS2456 and enantiomers as selective serotonin reuptake radiotracers for PET.

@article{Smith2001SynthesisAE,
  title={Synthesis and evaluation of racemic [(11)C]NS2456 and enantiomers as selective serotonin reuptake radiotracers for PET.},
  author={D. F. Smith and Dirk Bender and Katalin Marthi and Paul Cumming and S{\o}ren Baarsgaard Hansen and D. A. Peters and Elsebet {\O}stergaard Nielsen and J{\o}rgen Scheel-Kr{\"u}ger and Albert Gjedde},
  journal={Nuclear medicine and biology},
  year={2001},
  volume={28 3},
  pages={
          265-70
        }
}
[11C]‐NS 4194 versus [11C]‐DASB for PET imaging of serotonin transporters in living porcine brain
TLDR
Pretreatment of pigs with citalopram did not reduce the uptake of either tracer in cerebellum, validating the use of that tissue as a nonbinding reference tissue for kinetic analysis of specific binding, and in several respects superior to [11C]‐NS 4194 for the detection of serotonin uptake sites by PET.
Synthesis of the serotonin transporter ligand (±)‐10‐methyl 3‐[6‐nitro‐(2‐quinolinyl)]‐3,10‐diazabicyclo‐[4.3.1]‐decane ([11C‐methyl]NS 2495) and first in vivo results
TLDR
The serotonin transporter ligand (±)-10-[11C]-methyl 3-[6-nitro-(2-quinolinyl)]-3,10-diazabicyclo-[4.3.1]-decane ([11C-methyl]NS 2495) was synthesized via a methylation reaction with [11C]methyl iodide, and the specific radioactivity was found to be 1.8 GBq/μmol.
Synthesis of (±) 3‐(6‐nitro‐2‐quinolinyl)‐[9‐methyl‐11C]‐3,9‐diazabicyclo‐[4.2.1]‐nonane ([11C‐methyl]NS 4194)
(±) 3-(6-Nitro-2-quinolinyl)-[9-methyl-11C]-3,9-diazabicyclo-[4.2.1]-nonane ([11C-methyl]NS 4194), a selective serotonin reuptake inhibitor (SSRI), was synthesised within 35 min after end of
Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents.
  • R. Waterhouse
  • Biology, Chemistry
    Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging
  • 2003
PET Neuroimaging in Pigs
TLDR
Ten-years of PET findings on neuromolecular processes in the living porcine brain are reviewed and, whenever possible, PET findings in pigs are related to those obtained in humans.
Stereoselective neuroimaging in vivo
The use of pigs in neuroscience: Modeling brain disorders

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