Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.

@article{Zhang2012SynthesisAE,
  title={Synthesis and evaluation of piperidine urea derivatives as efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.},
  author={Liming Zhang and Junhua Chen and Mengmeng Ning and Qingan Zou and Ying Leng and Jianhua Shen},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 8},
  pages={2748-52}
}
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) has attracted considerable attention as a potential target for the treatment of diabetes and metabolic syndrome. Herein we report the design, synthesis and efficacy evaluation of novel amide and urea 11β-HSD1 inhibitors. Structure-activity relationship studies led to the identification of 10c, which was… CONTINUE READING