Synthesis and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.

Abstract

A total of 15 novel benzimidazole derivatives were designed, synthesized and evaluated for their SIRT1 and SIRT2 inhibitory activity. All compounds showed better inhibition on SIRT2 as compared to SIRT1. Among these, compound 5j displayed the best inhibitory activity for SIRT1 (IC50=58.43μM) as well as for SIRT2 (IC50=45.12μM). Cell cytotoxicity assays also… (More)
DOI: 10.1016/j.bmc.2013.12.029

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