Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.

Abstract

Novel 1-(2-acylhydrazinocarbonyl)cycloalkyl carboxamides were designed as peptidomimetic inhibitors of interleukin-1beta converting enzyme (ICE). A short synthesis was developed and moderately potent ICE inhibitors were identified (IC(50) values <100 nM). Most of the synthesized examples were selective for ICE versus the related cysteine proteases caspase-3… (More)

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@article{Soper2006SynthesisAE, title={Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.}, author={David Lindsey Soper and Justin X Sheville and Steven V O'neil and Yili Wang and Michael C Laufersweiler and Kofi A Oppong and John August Wos and Christopher D. Ellis and Amy N Fancher and Wei Lu and Maureen K Suchanek and Richard L. C. Wang and Biswanath De and Thomas Demuth}, journal={Bioorganic & medicinal chemistry letters}, year={2006}, volume={16 16}, pages={4233-6} }