Synthesis and evaluation of new polyenic compounds as potential PPARs modulators.

Abstract

In order to identify new leads for the treatment of type 2 diabetes, polyenic molecules A and B derived from nipecotic acid and dienol derivatives C have been prepared and their effect on PPARs transcriptional activity evaluated and compared to that of rosiglitazone, WY14,643 and GW501516. Among the synthesized compounds, dienol 39 is the most active, increasing WY14,643 PPARα response and demonstrating partial agonist properties on rosiglitazone PPARγ.

DOI: 10.1039/c2ob25593f

Cite this paper

@article{Amans2012SynthesisAE, title={Synthesis and evaluation of new polyenic compounds as potential PPARs modulators.}, author={Dominique Amans and V{\'e}ronique Bellosta and Catherine Dacquet and Alain Ktorza and Nathalie Hennuyer and Bart Staels and Daniel-Henri Caignard and Janine Cossy}, journal={Organic & biomolecular chemistry}, year={2012}, volume={10 30}, pages={6169-85} }