Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action.

@article{KisinFinfer2014SynthesisAE,
  title={Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action.},
  author={Einat Kisin-Finfer and Shiran Ferber and Rachel Blau and Ronit Satchi-Fainaro and Doron Shabat},
  journal={Bioorganic & medicinal chemistry letters},
  year={2014},
  volume={24 11},
  pages={2453-8}
}
Recent years have seen tremendous progress in the design and study of molecular imaging geared towards biological and biomedical applications. The expression or activity of specific enzymes including proteases can be monitored by cutting edge molecular imaging techniques. Cathepsin B plays key roles in tumor progression via controlled degradation of extracellular matrix. Consequently, this protease has been attracting significant attention in cancer research, and many imaging probes targeting… CONTINUE READING