Synthesis and evaluation of derivatives of leucine enkephalin as potential affinity labels for delta opioid receptors.

@article{Choi2003SynthesisAE,
  title={Synthesis and evaluation of derivatives of leucine enkephalin as potential affinity labels for delta opioid receptors.},
  author={Heekyung Choi and Thomas F. Murray and Jane V Aldrich},
  journal={Biopolymers},
  year={2003},
  volume={71 5},
  pages={552-7}
}
As part of an effort to develop peptide-based affinity labels for opioid receptors, [Leu(5)]enkephalin (LeuEnk) and DTLET (Tyr-D-Thr-Gly-Phe-Leu-Thr), potent agonists for delta receptors, were selected as the parent peptides for further modification. The affinity label derivatives were prepared using standard Fmoc solid-phase peptide synthesis in conjunction with Fmoc-Phe(p-NHAlloc) (Fmoc: 9-flourenylmethoxycarbonyl;) and selective modification of the p-amino group on this residue. The… CONTINUE READING