Synthesis and evaluation of cytotoxic activities of some substituted isoxazolone derivatives

  title={Synthesis and evaluation of cytotoxic activities of some substituted isoxazolone derivatives},
  author={S. Rollas and Şila Kokyan and B. Kaymakçıoğlu and S. Turan and J. Akbuǧa},
  journal={Marmara Pharmaceutical Journal},
Several isoxazolone derivatives were synthesized, starting from substituted 1,3,4-thiadiazoles and 1,2,4-triazole-3-thione. In the first part of the research, compounds 2-(4-aminophenyl)-5-alkyl/arylamino-1,3,4-thiadiazoles (4a-e) and 5-(4-aminophenyl)-4-sub- stitude-2,4-dihydro-3H-1,2,4-triazole-3-thiones (5a-c) were prepared from ethyl 4-aminoben- zoate. In the second part, compounds, which were prepared by coupling the diazonium salts of aromatic primary amines with ethyl acetoacetat (6a-e… Expand

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