Synthesis and evaluation of bromoacetoxy 4-androsten-3-ones as active site-directed inhibitors of human placental aromatase.

@article{Numazawa1986SynthesisAE,
  title={Synthesis and evaluation of bromoacetoxy 4-androsten-3-ones as active site-directed inhibitors of human placental aromatase.},
  author={Mitsuteru Numazawa and Masao Tsuji and Yoshio Osawa},
  journal={Steroids},
  year={1986},
  volume={48 5-6},
  pages={347-59}
}
2 alpha-Bromoacetoxy (II), 6-bromoacetoxy (VII and X), and 19-bromoacetoxy (XII) derivatives of androstenedione and 17 beta-bromoacetoxy compounds (III, IV, XIII-XVI) were synthesized as potential affinity-labeling reagents for aromatase. 6 alpha-Bromoacetoxy derivative VII was the most potent inhibitor of human placental microsomal aromatase activity among… CONTINUE READING