Synthesis and evaluation of bifunctional sGC regulators

Abstract

Background Our previous studies identified dicyanocobinamide as a novel sGC regulator that targets the catalytic region and synergistically enhances activation of sGC by NO-independent regulators. As proof-of-concept study, we designed and synthesized a set of bifunctional sGC regulators, which consist of cobinamide analog conjugated to a protoporphyrin IX… (More)
DOI: 10.1186/2050-6511-14-S1-P15

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