Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.

@article{OBoyle2010SynthesisAE,
  title={Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.},
  author={Niamh M O'Boyle and Miriam Carr and Lisa M. Greene and Orla E Bergin and Seema M. Nathwani and Thomas McCabe and David G. Lloyd and Daniela M. Zisterer and Mary J. Meegan},
  journal={Journal of medicinal chemistry},
  year={2010},
  volume={53 24},
  pages={8569-84}
}
The synthesis and antiproliferative activity of a new series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (β-lactam) ring system in place of the usual ethylene bridge present in the natural combretastatin stilbene products. These novel compounds are also substituted at position 3 of the β-lactam ring with… CONTINUE READING