Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands.

@article{Hartz2006SynthesisAE,
  title={Synthesis and evaluation of 2-anilino-3-phenylsulfonyl-6-methylpyridines as corticotropin-releasing factor1 receptor ligands.},
  author={Richard A Hartz and Argyrios G Arvanitis and Charles R Arnold and Joseph P Rescinito and Kimberly L Hung and Ge Zhang and Harvey Wong and David R. Langley and Paul J. Gilligan and George L Trainor},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 4},
  pages={934-7}
}
A novel series of 2-anilino-3-phenylsulfonyl-6-methylpyridines was synthesized and evaluated as corticotropin-releasing factor receptor ligands. Structure-activity relationship studies focused primarily on optimization of the 3-phenylsulfonyl group. Compounds within this series were identified which showed potent binding affinity for the CRF1 receptor. Selected compounds were examined in a rat pharmacokinetic study and were found to have oral bioavailabilities ranging from 16 to 35%.