Synthesis and evaluation of aplysinopsin analogs as inhibitors of human monoamine oxidase A and B.

Abstract

Aplysinopsins are tryptophan-derived natural products that have been isolated from a variety of marine organisms. Previous studies have shown aplysinopsin analogs to possess a variety of biological activities, including modulation of neurotransmissions. A series of fifty aplysinopsin analogs was synthesized and assayed for monoamine oxidase A and B… (More)
DOI: 10.1016/j.bmcl.2012.06.058

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