Synthesis and evaluation of antitubercular activity of fluorinated 5-aryl-4-(hetero)aryl substituted pyrimidines.

@article{Verbitskiy2016SynthesisAE,
  title={Synthesis and evaluation of antitubercular activity of fluorinated 5-aryl-4-(hetero)aryl substituted pyrimidines.},
  author={Egor V. Verbitskiy and Svetlana A Baskakova and Marionella A Kravchenko and S. N. Skornyakov and Gennady L. Rusinov and Oleg N Chupakhin and Valery N. Charushin},
  journal={Bioorganic & medicinal chemistry},
  year={2016},
  volume={24 16},
  pages={3771-80}
}
Various 5-(fluoroaryl)-4-(hetero)aryl substituted pyrimidines have been synthesized based on the Suzuki cross-coupling and nucleophilic aromatic substitution of hydrogen (SN(H)) reactions starting from commercially available 5-bromopyrimidine and their antitubercular activity against Mycobacterium tuberculosis H37Rv has been explored. The outcome of the study disclose that, some of the compounds have showed promising activity in micromolar concentration against Mycobacterium tuberculosis H37Rv… CONTINUE READING
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Synthesis and evaluation of antitubercular activity of fluorinated 5-aryl-4(hetero)aryl substituted pyrimidines, Bioorganic & Medicinal Chemistry

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Fluoroquinolones: Synthesis and Application, Fizmatlit

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