Synthesis and evaluation of analgesic, anti-inflammatory and antimicrobial activities of 6-acyl-3-piperazinomethyl-2-benzoxazolinones.

Abstract

In this study, 16 new 6-difluorobenzoyl-3-piperazinomethyl-2-benzoxazolinones were synthesized by Mannich reaction. Their chemical structures were proven by IR, 1H-NMR and elemental analysis. The compounds were screened for their analgesic and anti-inflammatory activities. A modified Koster test, using acetylsalicylic acid (ASA, CAS 50-78-2) as the… (More)

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Cite this paper

@article{Gkhan2003SynthesisAE, title={Synthesis and evaluation of analgesic, anti-inflammatory and antimicrobial activities of 6-acyl-3-piperazinomethyl-2-benzoxazolinones.}, author={Nesrin G{\"{o}khan and Hakki Erd{\~o}gan and N. Tugba Durlu and R{\"{u}meysa Demirdamar and Meral Ozalp}, journal={Arzneimittel-Forschung}, year={2003}, volume={53 2}, pages={114-20} }