Synthesis and evaluation of an N-acetylglucosamine biosynthesis inhibitor.

Abstract

The structural rationale, synthesis and evaluation of an inhibitor designed to block glucosamine synthesis by competitively inhibiting the action of glutamine: fructose-6-phosphate amidotransferase and subsequently reducing the transformation of any glucosamine-6-phosphate formed to UDP-N-acetylglucosamine are described. The inhibitor 2-acetamido-2,6… (More)
DOI: 10.1016/j.carres.2011.07.004

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