Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression.

@article{Kuge2009SynthesisAE,
  title={Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression.},
  author={Yuji Kuge and Naoyuki Obokata and Hiroyuki Kimura and Yumiko Katada and Takashi Temma and Yukihiko Sugimoto and Kazuki Aita and Koh-ichi Seki and N. Tamaki and Hideo Saji},
  journal={Nuclear medicine and biology},
  year={2009},
  volume={36 8},
  pages={869-76}
}
INTRODUCTION Despite extensive attempts to develop cyclooxygenase (COX)-2 imaging radiotracers, no suitable positron emission tomography (PET)/single photon emission computed tomography (SPECT) tracers are currently available for in vivo imaging of COX-2 expression. The aims of this study were to synthesize and evaluate a radioiodinated derivative of lumiracoxib, 2-[(2-fluoro-6-iodophenyl)-amino]-5-methylphenylacetic acid (FIMA), which is structurally distinct from other drugs in the class and… CONTINUE READING