Synthesis and evaluation of a radioiodinated 4,6-diaryl-3-cyano-2-pyridinone derivative as a survivin targeting SPECT probe for tumor imaging.

@article{Fuchigami2016SynthesisAE,
  title={Synthesis and evaluation of a radioiodinated 4,6-diaryl-3-cyano-2-pyridinone derivative as a survivin targeting SPECT probe for tumor imaging.},
  author={Takeshi Fuchigami and Tatsuya Mizoguchi and Natsumi Ishikawa and Mamoru Haratake and Sakura Yoshida and Yasuhiro Magata and Morio Nakayama},
  journal={Bioorganic & medicinal chemistry letters},
  year={2016},
  volume={26 3},
  pages={999-1004}
}
Survivin is overexpressed in most of the cancerous tissues but not in terminally differentiated normal tissues, making it an attractive target for diagnosis and therapy of various types of cancers. In this study, we aimed to develop 4,6-diaryl-3-cyano-2-pyridinone (DCP) derivatives, as novel cancer imaging probes that target survivin. Chloro and iodo… CONTINUE READING