Synthesis and evaluation of a 99mTc tricarbonyl-labeled somatostatin receptor-targeting antagonist peptide for imaging of neuroendocrine tumors.

@article{Radford2017SynthesisAE,
  title={Synthesis and evaluation of a 99mTc tricarbonyl-labeled somatostatin receptor-targeting antagonist peptide for imaging of neuroendocrine tumors.},
  author={Lauren Radford and Fabio A Gallazzi and Lisa D. Watkinson and Terry L. Carmack and Ashley Berendzen and Michael T. Lewis and Silvia S Jurisson and Dionysia Papagiannopoulou and Heather M. Hennkens},
  journal={Nuclear medicine and biology},
  year={2017},
  volume={47},
  pages={4-9}
}
INTRODUCTION A somatostatin receptor (SSTR)-targeting antagonist peptide (sst2-ANT) was radiolabeled with 99mTc tricarbonyl via a tridentate [N,S,N]-type ligand (L) to develop a radiodiagnostic agent, 99mTcL-sst2-ANT, for imaging of SSTR-expressing neuroendocrine tumors. METHODS Receptor affinity was assessed in vitro with the nonradioactive analogue, ReL-sst2-ANT, via a challenge experiment in AR42J cells with 125I-SS-14 as the competing radioligand. Preparation of 99mTcL-sst2-ANT was… CONTINUE READING

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