Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives.

  title={Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives.},
  author={Jay P Parrish and John D Trzupek and Terry V. Hughes and Inkyu Hwang and Dale L. Boger},
  journal={Bioorganic & medicinal chemistry},
  volume={12 22},
The preparation of a novel series of N-aryl CBI derivatives in which an aryl substituent could be used to predictably modulate the reactivity of the resulting CC-1065/duocarmycin alkylation subunit analogue is detailed and its extension to a unique series of N-alkenyl derivatives is reported. The N-aryl derivatives were found to be exceptionally stable and… CONTINUE READING