Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1protease activity.

@article{Wei2009SynthesisAE,
  title={Synthesis and evaluation of A-seco type triterpenoids for anti-HIV-1protease activity.},
  author={Ying Na Wei and Chao-Mei Ma and Masao Hattori},
  journal={European journal of medicinal chemistry},
  year={2009},
  volume={44 10},
  pages={
          4112-20
        }
}
2,3-Seco-dioic acids derived from four different triterpene skeletons were prepared and evaluated for their anti-HIV-1 protease activity. Two A-seco derivatives showed potent inhibitory activity against HIV-1 protease (3c and 3e, IC(50) 5.7 and 3.9 microM, respectively), while four other derivatives showed moderate to weak inhibition (3a, 3b, 3d and 3f, IC(50) 15.7-88.1 microM). The combination of a 2,3-seco-2,3-dioic acid functional group in ring A and a free acid group at C-28 or C-30… CONTINUE READING