Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents.

Abstract

Febrifugine is an alkaloid isolated from Dichroa febrifuga as the active component against Plasmodium falciparum. Adverse side effects have precluded febrifugine as a potential clinical drug. As part of an ongoing malaria chemotherapy project, novel febrifugine analogues were designed and synthesized. Lower toxicity of these newly designed compounds was… (More)
DOI: 10.1016/j.ejmech.2010.05.040

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@article{Zhu2010SynthesisAE, title={Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents.}, author={Shuren Zhu and Joe Wang and Gudise Chandrashekar and Erika L Smith and Xianjun Liu and Yongshen Zhang}, journal={European journal of medicinal chemistry}, year={2010}, volume={45 9}, pages={3864-9} }