Synthesis and evaluation of 2,5 and 2,6 pyridine-based CXCR4 inhibitors.


Targeting the interaction between G-Protein Coupled Receptor, CXCR4, and its natural ligand CXCL12 is a leading strategy to mitigate cancer metastasis and reduce inflammation. Several pyridine-based compounds modeled after known small molecule CXCR4 antagonists, AMD3100 and WZ811, were synthesized. Nine hit compounds were identified. These compounds showed… (More)
DOI: 10.1016/j.bmc.2016.08.018

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