Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain

@inproceedings{Yamasaki2013SynthesisAE,
  title={Synthesis and evaluation of [11C]MMPIP as a potential radioligand for imaging of metabotropic glutamate 7 receptor in the brain},
  author={Tomoteru Yamasaki and Katsushi Kumata and Joji Yui and Masayuki Fujinaga and Kenji Furutsuka and Akiko Hatori and Lin Xie and Masanao Ogawa and Nobuki Nengaki and Kazunori Kawamura and Ming-Rong Zhang},
  booktitle={EJNMMI Research},
  year={2013}
}
BackgroundMetabotropic glutamate 7 (mGlu7) receptor is a crucial target protein for the development of pharmaceuticals against central nervous system disorders. In the present study, we synthesized [11C]MMPIP, a putative radioligand for mGlu7 (binding constant KB = 30 nM), and evaluated its potential for imaging of mGlu7 via in vitro and in vivo techniques.Methods[11C]MMPIP was synthesized by the reaction of phenol precursor 3 with [11C]CH3I. In vitro autoradiography using [11C]MMPIP was… CONTINUE READING

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