Synthesis and evaluation as potential antitumor agents of novel ursolic acid derivatives

@article{Liu2016SynthesisAE,
  title={Synthesis and evaluation as potential antitumor agents of novel ursolic acid derivatives},
  author={Ming-Chuan Liu and Sheng-Jie Yang and Lin-Hong Jin and De-Yu Hu and Wei Xue and Song Yang},
  journal={Medicinal Chemistry Research},
  year={2016},
  volume={25},
  pages={2267-2279}
}
Novel ursolic acid derivatives were synthesized, and their structures were confirmed by MS, IR, 1H NMR and 13C NMR spectral analysis. In vitro antitumor activities of these compounds against MGC-803 (gastric cancer cell) and Bcap-37 (breast cancer cell) human cancer cell lines were evaluated by MTT assay. The pharmacological screening results revealed that many derivatives exhibited moderate to high activities against the tested cell lines, and that most demonstrated more potent inhibitory… CONTINUE READING

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