Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.

@article{Sadashiva2006SynthesisAE,
  title={Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.},
  author={Channangihalli Thimmegowda Sadashiva and J N Narendra Sharath Chandra and K C Ponnappa and Teregowda Veerabasappa Gowda and Kanchugarakoppal Subbegowda Rangappa},
  journal={Bioorganic & medicinal chemistry letters},
  year={2006},
  volume={16 15},
  pages={3932-6}
}
The cholinergic hypothesis of Alzheimer's disease (AD) has spurred the development of numerous structural classes of compounds with different pharmacological profile aimed at increasing central cholinergic neurotransmission. Thus proving a symptomatic treatment for this disease are cholinomimetics with the pharmacological profile of acetyl cholinesterase… CONTINUE READING