Synthesis and dual biological effects of hydroxycinnamoyl phenylalanyl/prolyl hydroxamic acid derivatives as tyrosinase inhibitor and antioxidant.

@article{Kwak2013SynthesisAD,
  title={Synthesis and dual biological effects of hydroxycinnamoyl phenylalanyl/prolyl hydroxamic acid derivatives as tyrosinase inhibitor and antioxidant.},
  author={S Y Kwak and Jin-Kyoung Yang and H Choi and Kyung-Chan Park and Young-Bu Kim and Y Lee},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 4},
  pages={1136-42}
}
We previously reported that caffeoyl-amino acidyl-hydroxamic acid (CA-Xaa-NHOH) acted as both a good antioxidant and tyrosinase inhibitor, in particular when caffeic acid was conjugated with proline or amino acids having aromatic ring like phenylalanine. Here, various hydroxycinnamic acid (HCA) derivatives were further conjugated with phenylalanyl hydroxamic acid and prolyl hydroxamic acid (HCA-Phe-NHOH and HCA-Pro-NHOH) to study the structure and activity relationship as both antioxidants and… CONTINUE READING

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The cell viability was tested using Cell Counting Kit-8 (CCK-8; CK04, Dojindo, Kumamoto, Japan)

Cell viability test
Mel-Ab cells (2 103 per well) were seeded into 96-well plates. Culture media were replaced with serum-free DMEM after 24 h, and incubated for another 24 h. Then, cells were treated with samples (100 lM) containing new serum-free media and incubated for 24 h. CCK-8 solution was added and cells were i • 2013

Pigm

S. Ito, K. Wakamatsu, H. Ozeki
Agric . Food Chem . • 2003

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