Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516.

@article{Ciocoiu2010SynthesisAD,
  title={Synthesis and dual PPARalpha/delta agonist effects of 1,4-disubstituted 1,2,3-triazole analogues of GW 501516.},
  author={Calin Constantin Ciocoiu and Nata{\vs}a Nikoli{\'c} and Huyen Hoa Nguyen and Gunn Hege Thoresen and Arne J{\o}rgeb Aasen and Trond Vidar Hansen},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 7},
  pages={
          3047-55
        }
}
Ten 1,4-disubstituted 1,2,3-triazoles 2a-2j were prepared and tested for their ability to increase oleic acid oxidation in human myotubes using a high-throughput multiwell assay. Compounds 2e (2-{4-[(1-(3-fluoro-4-(trifluoromethyl)phenyl)-1H-1,2,3-triazol-4-yl)methylthio]-2-methylphenoxy}acetic acid) and 2i (2-{4-[(1-(3-chloro-4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)methylthio]-2-methylphenoxy}acetic acid) exhibited potent agonist activities. Compounds 2e and 2i also exhibited… CONTINUE READING
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