Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors.

Abstract

Recently, deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug development as part of a new strategy of 5-fluorouracil-based combination chemotherapy. We have initiated a program to develop potent drug-like dUTPase inhibitors based on structure-activity relationship (SAR) studies of uracil derivatives. N-Carbonylpyrrolidine- and… (More)
DOI: 10.1021/jm201627n

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@article{Miyakoshi2012SynthesisAD, title={Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors.}, author={H. Miyakoshi and Seiji Miyahara and Tatsushi Yokogawa and Khoon Tee Chong and Junko Taguchi and Kanji Endoh and Wakako Yano and Takeshi Wakasa and H. Ueno and Yayoi Takao and Makoto Nomura and Satoshi Shuto and Hideko Nagasawa and Masayoshi Fukuoka}, journal={Journal of medicinal chemistry}, year={2012}, volume={55 7}, pages={2960-9} }