Synthesis and degradation of nucleic Acid components by formamide and cosmic dust analogues.

@article{Saladino2005SynthesisAD,
  title={Synthesis and degradation of nucleic Acid components by formamide and cosmic dust analogues.},
  author={Raffaele Saladino and Claudia Crestini and Veronica Neri and John Robert Brucato and Luigi Colangeli and Fabiana Ciciriello and Ernesto Di Mauro and Giovanna Costanzo},
  journal={Chembiochem : a European journal of chemical biology},
  year={2005},
  volume={6 8},
  pages={1368-74}
}
We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formamide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide. 

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